Table 9

Modification of staple strands for DNA origami
Triangular DNA origami
Not yet modified Modified staple strands
staple strands DINGet al. EGNAS
Average ΔG -1.5 ± 1.4 -3.2 ± 1.7 -2.2 ± 1.3
Minimum ΔG -5.2 -6.8 -5.2
Six-helix bundle nanotubes
Not yet modified Modified staple strands
staple strands STEARNSet al. EGNAS
Average ΔG -1.36 ± 1.1 -5.9 ± 1.3 -1.8 ± 1.4
Minimum ΔG -3.0 -8.0 -4.2

Comparison of sequences that were generated by using EGNAS, and those used by DING et al. [40] or STEARNS et al. [41] to modify staple strands of triangular DNA origami or six-helix bundle nanotubes, respectively. Molar free enthalpies (ΔG, kcal/mol) of the most stable hairpins. Averages ± standard deviations.

Kick et al.

Kick et al. BMC Bioinformatics 2012 13:138   doi:10.1186/1471-2105-13-138

Open Data