Figure 4.

Log-odd score for lost residues interactions (A) and for gained interactions (B). The red and blue zones correspond to damaging and neutral interactions respectively. The mutations resulting in the lost of a Cys-Cys and the gain of Trp-Trp interactions are mainly associated to insurgence of disease.

Capriotti and Altman BMC Bioinformatics 2011 12(Suppl 4):S3   doi:10.1186/1471-2105-12-S4-S3