Performance of the structural-based method. In panel (A), ROC curves of the sequence (SVM-SEQ) and structure-based methods (SVM-3D). The plot shows the improvement of 3% in AUC and 7% in TPR when sequence and structure base methods are compared. In panel B, accuracy and correlation coefficient of SVM-3D as function of the Reliability Index (RI). If predictions with RI>5 are selected the SVM-3D method results in 91% overall accuracy 0.82 correlation coefficient over 78% of the dataset. Accuracy measures (Q2, C, TPR and FPR) are defined in Methods section. DB is the fraction of the whole dataset of mutations.
Capriotti and Altman BMC Bioinformatics 2011 12(Suppl 4):S3 doi:10.1186/1471-2105-12-S4-S3