Figure 1.

Web interface structure. a) Query organ-specific genes by genes or proteins. For example, a UniGene ID, an Entrez gene ID, a gene name, a uniprot ID or IPI ID are all supported. To enter multiple values, delimit them by comma, semi-colon or space. b) advanced search. Query in customized ways, including referencing a list of genes/proteins, searching within p-value, z-score, number of EST, and adjusted number of EST ranges, or looking for organ-specific genes/proteins related to specific organ, disease MeSH ID, or dbEST library ID. c) browse organ-specific genes/organs by human organ system. d) browse organ-specific genes/organs by disease ontology. e) search result. In the gene/protein organ specificity table, it shows gene HMID, gene symbol, organ specificity, source, significance (p-value and z-score), and disease relevance. Users can further explore the histogram of the organ-specific gene/protein across the 52 organs by clicking on the histogram icon in the column of organ specificity, and its disease relevance by clicking on the disease relevance icon in the last column. f) histogram of organ-specific gene/protein. g) disease relevance of organ-specific gene/protein.