Workflow for the LSI based TF ranking for microarray derived gene sets. Microarray data was analyzed to identify differentially expressed genes (DEGs) in response to treatments. A list of 433 mouse TFs was derived from the TRANSFAC database and a significance test was conducted to identify TFs showing high average literature association with the entire set of DEGs relative to the entire gene population of 21,027 genes. TFs were ranked according to the literature-derived enrichment p-values.
Roy et al. BMC Bioinformatics 2011 12(Suppl 10):S19 doi:10.1186/1471-2105-12-S10-S19