A SegMine subgraph, where a strongly linked gene hub BRCA1 was identified. A part of the subgraph obtained by link search between two clusters of rules describing differentially expressed gene sets. All genes covered by the rules from clusters 1 and 9 of hierarchical clustering obtained from the MSC dataset were used. The subgraph allows for the Identification of BRCA1 and SMAD2 gene hubs. Some of the senescent candidate marker genes such as STAT1, MCM3, H2AFX, AURKA, RAD50, MRE11 are linked to the identified BRCA1 gene hub.
Podpečan et al. BMC Bioinformatics 2011 12:416 doi:10.1186/1471-2105-12-416