MAINE and FAIRE signal at TSSs of genes segregated by time of expression. Each panel plots the time series from the chromatin experiments versus the gene expression labels. The value in each cell, indicated by color, corresponds to the mean MAINE or FAIRE measurement around TSSs of genes with the given label. These values have been row-normalized to the range [0, 1]. The horizontal bar within each cell indicates the magnitude of the standard deviation, relative to all other cells. Panel (A) uses gene expression labels derived from the sorbitol-synchronized cell cycle, whereas panel (B) uses labels derived from the temperature cycling incubator synchronized cell cycle. In both panels, the vertical and horizontal axes of the heat maps shown have been ordered using hierarchical clustering.
Buske et al. BMC Bioinformatics 2011 12:415 doi:10.1186/1471-2105-12-415