Effect of including replicate information on noisy clusters. Using replicate information can split a noisy cluster into smaller more biologically homogeneous clusters with distinct profiles. The examples shown use BHC-C for the S. cerevisiae 2 data set and BHC-SE for the H. sapiens and E. coli data sets. *For this cluster of only two genes, instead of considering the BHI, we looked directly at the biological functions of the genes.
Cooke et al. BMC Bioinformatics 2011 12:399 doi:10.1186/1471-2105-12-399