Comparisons of cell chain probability distribution functions with cell population NDFs. Panel (a): For the population distribution, a batch of 20 simulations was run with Ncellsmax = 500, [Iex] = 24 μM and the nominal parameter set (Table 3) and sampled at t = 500 min. For the cell chain simulation, tfinal = 105 min and samples were taken periodically in time with Δt = 10 min. Panel (b): as in panel (a) but with 100-fold faster lacY transcription (ks1MY = 50 min-1, ks1MY = 1 min-1) and slower translation (ksY = 0.3 min-1). The simulation batch consisted of 20 simulations and was sampled at t = 250 min. The cell line was tracked for 105 min of simulated time.
Stamatakis and Zygourakis BMC Bioinformatics 2011 12:301 doi:10.1186/1471-2105-12-301