Table 6

5 More # of non-H, # of non-H polar bonds and # of rotatable bonds could increase the potency of HCV NS5B Inhibitors.

Precursor

Structure

IC50(uM)NS5B


#15

IC50(uM)NS5B: 1.64

+ 2.51%

(× 25.2)


#15

IC50(uM)NS5B: 1.64

+ 2.18%

(× 24.5)


#15

IC50(uM)NS5B: 1.64

+ 1.63%

(× 27.5)


#15

IC50(uM)NS5B: 1.64

+ 1.19%

(× 24.1)


#15

IC50(uM)NS5B: 1.64

+ 0.98%

(× 24.1)


#15

IC50(uM)NS5B: 1.64

+ 0.91%

(× 24.3)


#15

IC50(uM)NS5B: 1.64

+ 0.79%

(× 24.2)


Liu et al. BMC Bioinformatics 2011 12:294   doi:10.1186/1471-2105-12-294

Open Data