Performance comparison with no network latency. Comparison of runtimes with the client software and server on the same machine. To separate the effects of network throughput and latency from those of the disk and CPU, we ran the test suite from the server machine. The ReadDB test still went through the ReadDB server and the BAM and WIG files were read by the httpd process. These tests indicate that ReadDB's fast queries compared to remote BAM are not the result of BAM queries passing more information across the network; the ReadDB queries through the ReadDB server are faster than either BAM through httpd or BAM read directly from local disk.
Rolfe and Gifford BMC Bioinformatics 2011 12:278 doi:10.1186/1471-2105-12-278