Figure 3.

Identification of putative enhancers. This workflow shows the identification of putative enhancers, by progressively filtering the distal peaks with histone modification enhancer marks (i.e., presence of H3K4me1 and absence of H3K4me3) and CBP binding. De novo motif discovery and conservation analysis were then performed, which showed highly enriched ETS-domain motifs and high conservation scores in the set of putative enhancers compared to random regions.

Giannopoulou and Elemento BMC Bioinformatics 2011 12:277   doi:10.1186/1471-2105-12-277
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