Predicting functionally important SNP classes based on negative selection
1Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065 USA
BMC Bioinformatics 2011, 12:26 doi:10.1186/1471-2105-12-26Published: 19 January 2011
Additional file 1:
Evidence for negative selection among various annotation classes. Comparison of derived allele frequency for all classes against both ancestral repeats and the whole genome is shown for all three Perlegen populations. Yellow shaded classes are statistically significant when we apply an FDR correction with α = 0.05. Only resequenced Perlegen SNP markers are included in this analysis to minimize ascertainment bias. The file can be viewed with Microsoft Excel.
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