Table 3

Brain data: Biological relevance of some of the selected genes

Bard1

Plays a central role in the control of the cell cycle in response to DNA damage

PGDH

Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system

Na(v) Beta1

Involved in the generation and propagation of action potentials in muscle and neuronal cells

NDF1

Differentiation factor required for dendrite morphogenesis and maintenance in the cere bellar cortex

Neuronatin

May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system

PEA15

death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes

CD97

Receptor potentially involved in both adhesion and signalling processes early after leukocyte activation. Plays an essential role in leukocyte migration

ALDOC

is expressed specifically in the hippocampus and Purkinje cells of the brain

Cyclin D1

The protein encoded by this gene has been shown to interact with tumor suppressor protein Rb Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumour genesis


Description of the genes or proteins encoded by the genes selected by sPLS-DA and present in the known GeneGO biological network.

LĂȘ Cao et al. BMC Bioinformatics 2011 12:253   doi:10.1186/1471-2105-12-253

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