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Open Access Highly Accessed Methodology article

New methods to measure residues coevolution in proteins

Hongyun Gao12, Yongchao Dou12, Jialiang Yang3 and Jun Wang45*

Author Affiliations

1 School of Mathematical Sciences, Dalian University of Technology, 116024 Dalian, People's Republic of China

2 College of Advanced Science and Technology, Dalian University of Technology, 116024 Dalian, People's Republic of China

3 MPI-CAS Institute of Computational Biology, Chinese Academy of Sciences at Shanghai, 200031 Shanghai, People's Republic of China

4 Scientific Computing Key Laboratory of Shanghai Universities, 200234 Shanghai, People's Republic of China

5 Department of Mathematics, Shanghai Normal University, 200234 Shanghai, People's Republic of China

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BMC Bioinformatics 2011, 12:206  doi:10.1186/1471-2105-12-206

Published: 26 May 2011

Additional files

Additional file 1:

Data sets. All MSAs used in the study are given in the file 'Additional-File-1.zip'.

Format: ZIP Size: 582KB Download file

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Additional file 2:

Results. A zip file (Addtional-File-2.zip) contains all results on above data sets.

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Additional file 3:

Perl Code. A zip file (Perl-codes.zip) contains all Perl codes used in the study.

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Additional file 4:

Effects of sequence identity. The supplement material includes the comparisons of these proposed methods on different sequence identities based on the 1JXA-A family. Their corresponding JSD ranks are also shown in the material.

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