Figure 1.

Human interactome from I2D ver. 1.9 http://ophid.utoronto.ca/i2d webcite - 278,214 physical protein-protein interaction (of which 158,549 are unique), connecting 14,641 proteins. Using concentric circle layout, Sanger CENSUS cancer genes are used as a root (523 proteins connected directly by 1,180 interactions), and proteins with fewer than 51 interacting partners are collapsed in the two central points (to reduce number of objects and make the resulting SVG file editable in Adobe Illustrator). Node size corresponds to node degree, and node color corresponds to GeneOntology biological function. Visualization was done in NAViGaTOR ver. 2.2.1 http://ophid.utoronto.ca/navigator webcite.

Yakhini and Jurisica BMC Bioinformatics 2011 12:120   doi:10.1186/1471-2105-12-120
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