Predicted Intrachromosomal Fusion Genes in GBM. (A) The INTS2-MED13 rearrangement on Chromosome 17 is identified in 9 individuals and arises from an amplification. A tandem duplication that affects the 3' end of MED13 and the 5' end of INTS2 will fuse the promoter region of INTS2 to MED13. (B) The PPP1R9A-PSMC2 rearrangement on Chromosome 7 is identified in 6 individuals and arises from a deletion.
Ritz et al. BMC Bioinformatics 2011 12:114 doi:10.1186/1471-2105-12-114