Predicted Gene Truncations in GBM. These three recurrent gene breakpoints found on Chromosome 7, Chromosome X, and Chromosome 6 respectively suggest truncations of genes associated with glioblastoma or other neuronal diseases. (A) The recurrent breakpoint in ECOP has a large change in copy number; this gene is near EGFR and is the breakpoint location for the EGFR amplification. (B) PCDH11X appears to arise from a short deletion within a relatively amplified region, though the deletion breakpoint varies within the PCDH11X gene region. (C) RUNX2 contains two probe locations with recurrent probe breakpoints that each have small copy number change at approximately 45.42 Mb and 45.58 Mb.
Ritz et al. BMC Bioinformatics 2011 12:114 doi:10.1186/1471-2105-12-114