A brief of HUNTER. (A) The flowchart of HUNTER. (B) An example of DNA Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination. An example of HUNTER predict cluster, a ten-protein cluster. The module seed of this cluster consists of one protein in yellow (YAR007C) and five proteins in pink (YJL173C, YCR028C-A, YML032C, YNL312W, and YHR164C) in the dashed circle. Among these six proteins, five proteins (YAR007C, YJL173C, YCR028C-A, YML032C, and YNL312W) form a fully connected subgraph (clique) in the PPI network. Proteins in green, YCR092C, YMR234W, YKL114C, and YER095W are the attachments to the module seed.
Chin et al. BMC Bioinformatics 2010 11(Suppl 1):S25 doi:10.1186/1471-2105-11-S1-S25