Resolution:
## Figure 8.
Comparison of normalization procedures: Goodness-of-fit of Poisson model. The multiplicative Poisson model (GLM 1 in [Additional file 2: Supplemental Table S4]) is fit to the seven Brain lanes in the MAQC-2 experiment
after (a) total-count, (b) POLR2A, (c) upper-quartile, and (d) quantile normalization.
Goodness-of-fit statistics are computed and displayed in χ^{2 }quantile-quantile plots. Genes with goodness-of-fit statistics in the top quantiles
of the χ^{2}-distribution are displayed using colored plotting symbols: red (1, 5]%, purple (.1,
1]%, gold [0, .1]%. Similar plots for UHR show the same patterns.
Bullard |