True (red) vs. estimated (blue) log-rate values and selected molecular dynamics in the unperturbed biochemical reaction system depicted in Figure 1. The results are based on measuring the dynamics in the unperturbed and perturbed systems at Q = 6 logarithmically-spaced time points (green circles). Perturbations are applied on the initial concentrations of Shc*, Grb2, and Sos, one at a time. The measurement errors are i.i.d. zero-mean Gaussian with standard deviation σ = 0.3.
Jenkinson et al. BMC Bioinformatics 2010 11:547 doi:10.1186/1471-2105-11-547