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Open Access Research article

Thermodynamically consistent Bayesian analysis of closed biochemical reaction systems

Garrett Jenkinson1, Xiaogang Zhong2 and John Goutsias1*

Author Affiliations

1 Whitaker Biomedical Engineering Institute, The Johns Hopkins University, Baltimore, MD 21218, USA

2 Department of Applied Mathematics and Statistics, The Johns Hopkins University, Baltimore, MD 21218, USA

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BMC Bioinformatics 2010, 11:547  doi:10.1186/1471-2105-11-547

Published: 5 November 2010

Additional files

Additional file 1:

In this document, we provide theoretical details necessary to understand the Bayesian analysis approach introduced in the Main text.

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Additional file 2:

This document contains a detailed description of the computational algorithms used for implementing various steps of the proposed Bayesian analysis approach.

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Additional file 3:

In this document, we list the biochemical reactions associated with our numerical example and provide thermodynamically consistent values for the rate constants as well as appropriate values for the initial molecular concentrations.

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