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Open Access Highly Accessed Methodology article

An exploratory data analysis method to reveal modular latent structures in high-throughput data

Tianwei Yu

Author Affiliations

Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, USA

BMC Bioinformatics 2010, 11:440  doi:10.1186/1471-2105-11-440

Published: 27 August 2010

Abstract

Background

Modular structures are ubiquitous across various types of biological networks. The study of network modularity can help reveal regulatory mechanisms in systems biology, evolutionary biology and developmental biology. Identifying putative modular latent structures from high-throughput data using exploratory analysis can help better interpret the data and generate new hypotheses. Unsupervised learning methods designed for global dimension reduction or clustering fall short of identifying modules with factors acting in linear combinations.

Results

We present an exploratory data analysis method named MLSA (Modular Latent Structure Analysis) to estimate modular latent structures, which can find co-regulative modules that involve non-coexpressive genes.

Conclusions

Through simulations and real-data analyses, we show that the method can recover modular latent structures effectively. In addition, the method also performed very well on data generated from sparse global latent factor models. The R code is available at http://userwww.service.emory.edu/~tyu8/MLSA/ webcite.