Open Access Highly Accessed Methodology article

A statistical method for excluding non-variable CpG sites in high-throughput DNA methylation profiling

Hailong Meng1,4*, Andrew R Joyce2, Daniel E Adkins3, Priyadarshi Basu1, Yankai Jia1, Guoya Li1,5, Tapas K Sengupta1,6, Barbara K Zedler2, E Lenn Murrelle2 and Edwin JCG van den Oord3

1 Altria Client Services, Research Development & Engineering, 601 E. Jackson Street, Richmond, VA 23219, USA

2 Venebio Group, LLC, Virginia Bio-Technology Research Park, Richmond, Virginia, USA

3 Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA

4 Memorial Sloan-Kettering Cancer Center, 415 East 68th Street, New York, NY 10021, USA

5 Bon Secours Virginia Health System, 14331 Roderick Ct., Midlothian, VA 23113, USA

6 American Type Culture Collection, 10801 University Blvd, Manassas, VA 20110, USA

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BMC Bioinformatics 2010, 11:227 doi:10.1186/1471-2105-11-227

Published: 5 May 2010

Additional files

Additional file 1:

Supplementary Material. Technical details of the study, including methylation status calculation, measures of lung function and decline, and supplementary figures.

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