Table 1

Genes with significant mutation clusters (Probability < 0.01)

Gene

Cluster

size

Cluster

positions

Number of

mutations in

cluster

Cumulative cluster

probability*


KRAS (188 aa)

2

12-13

131

1.47E-234


BRAF (766 aa)

1

600-600

60

2.02E-157


TP53 (393 aa)

155

132-286

326

3.07E-101


NRAS (189 aa)

1

61-61

33

7.11E-62


PIK3CA (1068 aa)

5

542-546

27

7.09E-46


CTNNB1 (781 aa)

13

33-45

12

8.54E-19


ERBB2 (1255 aa)

1

776-776

2

7.97e-4


HRAS (189 aa)

1

61-61

4

2.06E-06


PTEN (403 aa)

63

111-173

8

5.50E-05


MAP2K7 (419 aa)

1

162-162

2

0.002386


LRRK2 (2534 aa)

4

1723-1726

2

0.003547


*: only most significant cluster per gene is listed

Ye et al. BMC Bioinformatics 2010 11:11   doi:10.1186/1471-2105-11-11

Open Data