Table 8

Summary of the prediction results of the 10 most frequent mutations and their related drugs extracted from text compares with the HIVDB on two levels and three levels of resistance: susceptible (S), intermediate resistant (I), and resistant (R).

Mutation

Drugs

Agreement with the Stanford HIVDB output (%)

Two levels: S, R

Three levels: S, I, R

I84V

ATV, IDV, LPV, NFV, SQV, TPV

6/6

6/6

K103N

AZT, DLV, EFV, NVP

3/4

6/6

K65R

3TC, ABC, AZT, D4T, DDI, FTC, TDF

7/7

7/7

L74V

3TC, ABC, AZT, D4T, DDI

3/5

3/5

L90M

ATV, IDV, LPV, NFV, SQV

5/5

4/5

M184V

3TC, ABC, AZT, D4T, DDI, EFV, FTC, NVP, TDF

6/9

7/9

M46I

ATV, IDV, NFV, SQV

3/4

2/4

Q151M

3TC, ABC, AZT, D4T, DDI

5/5

3/5

V82A

IDV, LPV, NFV, SQV

4/4

3/4

Y181C

AZT, D4T, DLV, EFV, NVP

4/5

3/5

Over all

85%

76%

Bui et al. BMC Bioinformatics 2010 11:101   doi:10.1186/1471-2105-11-101