Figure 5.

PLS analysis of type 2 diabetic samples (57) and healthy samples (41) using Automics. (A) PLS scores show evident clustering between diabetic (○) and healthy (△) samples. The optimal separation occurs in the second and third components (t2, t3). (B) Regression coefficients of the corresponding PLS model. (C) PLS scores after application of DOSC for removal of one orthogonal component. (D) Regression coefficients of the PLS model after application of DOSC. (E) PLS scores after application of O-PLS. Note that the significant improvement for separation is both achieved by DOSC and O-PLS, and now the optimal separation occurs in the first principal component. (F) Regression coefficients of the PLS model after application of O-PLS.

Wang et al. BMC Bioinformatics 2009 10:83   doi:10.1186/1471-2105-10-83
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