Edge detection on the tube formation assay. The edge detection scheme applied to the image on the top left (a) from a tube formation assay, where endothelial cells form vessels (or tubes). The results of the edge detection using levels 4 and 5 of the 6 curvelet levels are shown in (b), with a close-up of a region shown in image (c). For the last image (d), we have also indicated the sheet-like structures, detected as areas where the sum of the curvelet coefficients over all directions is larger than a threshold. Before thresholding, we computed the opening of the image generated from these sums of coefficients to make the detected areas more connected.
Gebäck and Koumoutsakos BMC Bioinformatics 2009 10:75 doi:10.1186/1471-2105-10-75