Table 8

Functions of each conventional DC subtype.

antigen processing activity

cytokine secretion activity

macro- pinocytosis activity

T cell antigen presentation activity

antigen transportation activity


CD8α-CD11b- DC

+

+

immature

+

+

+

+

+

CD8α-CD11b- DC

mature

+

+

CD8α-CD11b- DC


CD8α- CD11b+ DC

+

+

immature

+

+

+

+

+

CD8α- CD11b+ DC

mature

+

+

CD8α- CD11b+ DC


CD8α + CD11b- DC

+

+

immature

+

+

+

+

+

CD8α + CD11b- DC

mature

+

+

CD8α + CD11b- DC


interstitial DC

+

+

immature

+

+

+

+

+

interstitial DC

mature

+

+

interstitial DC


Langerhans cell

+

+

CD1a+ Langerhans cell

+

+

immature CD1a+

+

+

+

+

+

Langerhans cell

mature CD1a+

+

+

Langerhans cell

CD8αlow Langerhans cell

+

+

immature CD8αlow

+

+

+

+

+

Langerhans cell

mature CD8αlow

+

+

Langerhans cell


dermal DC

+

+

immature dermal DC

+

+

+

+

+

mature dermal DC

+

+


+ indicates that the cell type referred to by the row label is related to the function indicated by the column heading using the has_function relation.

Masci et al. BMC Bioinformatics 2009 10:70   doi:10.1186/1471-2105-10-70

Open Data