Table 2

Surface protein combinations defining the subtypes of conventional dendritic cell.

205

11b

4

1a

206

209

36

14

207

324

80

83

86

MHC

II


CD8α-CD11b- DC

+

-

-

-

immature

+

-

-

-

L

L

L

CD8α-CD11b- DC

mature

+

-

-

-

H

+

H

H

CD8α-CD11b- DC


CD8α- CD11b+ DC

-

+

+

-

immature

-

+

+

-

L

L

L

CD8α- CD11b+ DC

mature

-

+

+

-

H

+

H

H

CD8α- CD11b+ DC


CD8α + CD11b- DC

+

-

-

+

immature

+

-

-

+

L

L

L

CD8α + CD11b- DC

mature

+

-

-

+

H

+

H

H

CD8α + CD11b- DC


interstitial DC

+

+

+

+

immature

+

+

+

+

L

L

L

interstitial DC

mature

+

+

+

+

H

+

H

H

interstitial DC


Langerhans cell

+

CD1a+ Langerhans cell

+

+

+

immature CD1a+

+

+

+

L

L

L

Langerhans cell

mature CD1a+

+

+

+

H

+

H

H

Langerhans cell

CD8αlow Langerhans cell

H

L

+

immature CD8αlow

H

L

+

L

L

L

Langerhans cell

mature CD8αlow

H

L

+

H

+

H

H

Langerhans cell


dermal DC

+

+

-

immature dermal DC

+

+

-

L

L

L

mature dermal DC

+

+

-

H

+

H

H


Column headings show protein or protein complex names. Numbers correspond to CD antigens (e.g. CD205 is referred to as 205 in the table). Row labels show the terms for subtypes of conventional dendritic cell defined in DC-CL. Row labels not indented correspond to direct subtypes of conventional dendritic cell; indented row labels correspond to direct subtypes of the types referred to by the nearest, above row with less indent. + indicates that the has_plasma_membrane_part relation is use to join the cell type term to the protein or protein complex term; – indicates that the lacks_plasma_membrane_part relation is used; L indicates that the has_low_plasma_membrane_amount relation is used; and H indicates that the has_high_plasma_membrane_amount relation is used.

Masci et al. BMC Bioinformatics 2009 10:70   doi:10.1186/1471-2105-10-70

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