Table 10

Dispositions of the conventional DC subtypes.

disposition to circulate in the blood

disposition to cross-present antigen to CD8+ T cells

disposition to migrate to the lymph node

disposition to secrete anti- inflammatory cytokines

disposition to secrete inflammatory cytokines

disposition to secrete type 1 interferon


CD8α-CD11b- DC

immature

CD8α-CD11b-DC

mature

+

CD8α-CD11b-DC


CD8α- CD11b+ DC

+

immature

+

CD8α- CD11b+DC

mature

+

CD8α- CD11b+DC


CD8α + CD11b-DC

+

+

immature

+

+

CD8α + CD11b-DC

mature

+

+

CD8α + CD11b-DC


interstitial DC

immature

+

interstitial DC

mature

interstitial DC


Langerhans cell

CD1a+

Langerhans cell

immature

+

CD1a+

Langerhans cell

mature

CD1a+

Langerhans cell

CD8αlow

+

+

Langerhans cell

immature

+

+

CD8αlow

Langerhans cell

mature

+

+

CD8αlow

Langerhans cell


dermal DC

immature

+

dermal DC

mature dermal DC


+ indicates the cell type referred to by the row label is related to the disposition referred to by the column heading using the has_disposition relation.

Masci et al. BMC Bioinformatics 2009 10:70   doi:10.1186/1471-2105-10-70

Open Data