Table 4 |
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Potentially-druggable PPIs predicted by the SVM-based method. a |
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PPI |
PPI |
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|
|
|
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|
Protein 1 |
Protein 2 |
Protein 1 |
Protein 2 |
|
|
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|
APC |
CTNNB1 |
CTNNB1 |
CTNNBIP1 |
|
ARHGAP1 |
CDC42 |
E2F2 |
RB1 |
|
ARHGDIA |
CDC42 |
EGFR |
ERRFI1 |
|
ARHGDIA |
RAC1 |
EP300 |
CITED2 |
|
ARHGDIA |
RAC2 |
EP300 |
HIF1A |
|
BCL2L1 |
BECN1 |
EP300 |
MYB |
|
BCL9 |
CTNNB1 |
GSK3B |
AXIN1 |
|
CALM1 |
KCNN2 |
HRAS |
RALGDS |
|
CALM1 |
RYR1 |
HRAS |
RASA1 |
|
CALM2 |
MARCKS |
MAX |
MYC |
|
CD247 |
SHC1 |
NCF2 |
RAC1 |
|
CDC42 |
ITSN1 |
NFKB1 |
TXN |
|
CDC42 |
MCF2L |
NFKBIB |
RELA |
|
CDC42 |
WAS |
RAC1 |
ARFIP2 |
|
CDH1 |
CTNNB1 |
RAF1 |
RAP1A |
|
CREBBP |
CITED2 |
RPA1 |
TP53 |
|
CREBBP |
HIF1A |
S100B |
TP53 |
|
CREBBP |
IRF3 |
SMAD2 |
ZFYVE9 |
|
CREBBP |
MYB |
SMAD4 |
SKI |
|
CTNNA1 |
JUP |
TP53 |
TP53BP1 |
|
CTNNB1 |
BTRC |
TP53 |
TP53BP2 |
|
|
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aFor details, see Additional file 1: Table S3. PPIs were listed if an instance of the PPIs had the druggability scores of >9,000 by the SVM model using all attributes and >6,500 by the model using the top 10 attributes by F-score. |
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Sugaya and Ikeda BMC Bioinformatics 2009 10:263 doi:10.1186/1471-2105-10-263 |
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