Determining non-redundant CGI profiles. Elimination of redundant CGI profiles. Initially, 55 profiles (relations between CGI sequence attributes and methylation classes linked by the probability of intersection) were identified. We grouped all profiles recognizing the same observation using a column/row hierarchical clustering, and summarize each cluster by their most representative prototype (i.e., the most supported relation of each cluster). The validity index we used (see methods) suggests a partition into 9 final profiles.
Previti et al. BMC Bioinformatics 2009 10:116 doi:10.1186/1471-2105-10-116