Table 3 |
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|
Top30 mediators with prioritized sorting excluding midbody queries. |
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|
Ranks by Hub Degree |
Gene Symbol |
Hub Degree |
Total Degree |
Annotation |
Ranks by S3 Score |
Gene Symbol |
Hub Degree |
Total Degree |
Annotation |
|
|
|||||||||
|
1 |
GRB2 |
36 |
407 |
1 |
HTR3A |
2 |
2 |
membrane |
|
|
2 |
YWHAZ |
27 |
391 |
2 |
KIAA0133 |
2 |
2 |
membrane |
|
|
3 |
IKBKE |
24 |
328 |
3 |
PPP1R14B |
2 |
2 |
||
|
4 |
TRAF6 |
24 |
369 |
4 |
DOCK7 |
2 |
3 |
Rho |
|
|
5 |
HLA-B |
20 |
273 |
membrane |
5 |
GEFT |
2 |
3 |
Rho |
|
6 |
MAP3K3 |
18 |
173 |
6 |
LCT |
2 |
3 |
membrane |
|
|
7 |
ACTB |
17 |
187 |
7 |
OPHN1 |
2 |
3 |
Rho |
|
|
8 |
YWHAG |
16 |
309 |
8 |
PLEKHG2 |
2 |
3 |
Rho |
|
|
9 |
RIPK3 |
15 |
88 |
9 |
MYT1 |
2 |
3 |
||
|
10 |
IKBKG |
15 |
155 |
cytokinesis |
10 |
PLEKHM2 |
2 |
3 |
membrane |
|
11 |
MCC |
14 |
217 |
11 |
TOR1AIP1 |
2 |
3 |
membrane |
|
|
12 |
EGFR |
14 |
261 |
membrane |
12 |
MALL |
2 |
3 |
membrane |
|
13 |
MYC |
13 |
322 |
13 |
ARPC5 |
5 |
9 |
actin |
|
|
14 |
TP53 |
12 |
315 |
cytokinesis |
14 |
FLOT2 |
3 |
6 |
membrane |
|
15 |
CASP3 |
11 |
139 |
15 |
ESPL1 |
2 |
4 |
cytokinesis |
|
|
16 |
EIF1B |
11 |
153 |
16 |
ASPM |
2 |
4 |
cytokinesis |
|
|
17 |
CDH1 |
10 |
80 |
membrane |
17 |
CASC3 |
2 |
4 |
membrane |
|
18 |
PRKCA* |
10 |
181 |
Rho |
18 |
CD163 |
2 |
4 |
membrane |
|
19 |
VHL |
10 |
208 |
membrane |
19 |
MCF2L |
2 |
4 |
Rho |
|
20 |
SRC |
10 |
217 |
cytokinesis |
20 |
DIS3L2 |
2 |
4 |
|
|
21 |
ACTA1 |
9 |
103 |
actin |
21 |
KTN1 |
3 |
7 |
cytokinesis |
|
22 |
DISC1 |
9 |
113 |
22 |
ARPC4 |
5 |
13 |
actin |
|
|
23 |
EPB41 |
9 |
128 |
23 |
SRGAP1 |
2 |
5 |
Rho |
|
|
24 |
TNFRSF1A |
9 |
128 |
24 |
RPRM |
2 |
5 |
membrane |
|
|
25 |
CFTR |
9 |
135 |
membrane |
25 |
SEC24D |
2 |
5 |
|
|
26 |
PRKAB1 |
9 |
153 |
26 |
NRAP |
2 |
5 |
actin |
|
|
27 |
FYN |
9 |
161 |
cytokinesis |
27 |
PLP1 |
2 |
5 |
membrane |
|
28 |
SMAD3 |
9 |
193 |
28 |
SEPT11 |
2 |
5 |
cytokinesis |
|
|
29 |
GH1 |
8 |
76 |
29 |
ABCC2 |
2 |
5 |
membrane |
|
|
30 |
EIF6 |
8 |
101 |
30 |
ACP6 |
3 |
9 |
membrane |
|
|
|
|||||||||
|
|
|||||||||
|
Putative Midbody Related Proteins |
11 |
(37%) |
Putative Midbody Related Proteins |
26 |
(87%) |
||||
|
Actin |
1 |
(3%) |
Actin |
3 |
(10%) |
||||
|
Cytokinesis |
4 |
(13%) |
Cytokinesis |
4 |
(13%) |
||||
|
Membrane |
5 |
(17%) |
Membrane |
13 |
(43%) |
||||
|
Rho proteins |
1 |
(3%) |
Rho proteins |
6 |
(20%) |
||||
|
Unknown Proteins |
19 |
(63%) |
Unknown Proteins |
4 |
(13%) |
||||
|
|
|||||||||
|
The top 30 proteins ranked by hub degree (left) and sub-network specificity score (S3, right) and analyzed for their ability to enrich midbody-related proteins. * PRKCA is both a Rho protein and a cytokinesis related protein. It is classified as Rho protein to simplify the ratio calculation. |
|||||||||
|
Lee et al. BMC Bioinformatics 2009 10:114 doi:10.1186/1471-2105-10-114 |
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