Table 2 |
|
|
Comparison of rHSulf-2 requirements for mobilization of heparin-bound ligands |
|
|
Ligand |
Concentration required for 50% release of heparin-bound ligand |
|
|
|
|
rHSulf-2 (μg/mL) |
|
|
|
|
|
VEGF |
0.34 |
|
FGF-1 |
0.36 |
|
FGF-2 |
>4.0 |
|
CXCL12 (SDF-1) |
0.44 |
|
CCL21 (SLC) |
3.1 |
|
CXCL8 (IL-8) |
3.4 |
|
CXCL10 (IP-10)a |
2.0 |
|
|
|
|
a Kd for heparin-BSA was 62 nM. The fixed concentration of ligand tested in the assay was 50 nM. |
|
|
Uchimura et al. BMC Biochemistry 2006 7:2 doi:10.1186/1471-2091-7-2 |
|
