Figure 6.

Proposed regulation of Rho signaling. The Rho signaling pathway may play an important role in the mechanism of gravity sensation in cells. Our results indicate that the gene expression of RhoGEF (LARG) is downregulated under simulated microgravity. As a result of the downregulation, the activation level of Rho becomes lower and the actin fibers are subsequently disorganized. The upstream and/or downstream regulation of Rho signaling may be involved in the process that converts the gravity signal into the intercellular signal.