Figure 7.

Sensorgrams of Cry1A toxins and hybrid toxin binding to purified native B. mori receptors. SPR response units (RU) are at left. Shown are overlaid traces of Cry1Aa, Cry1Ab, Cry1Ac and hybrid toxin 4109, consisting of domains I and II from Cry1Aa and domain III from Cry1Ac (Aa/Aa/Ac). (A) Toxin injection (500 nM) over immobilized aminopeptidase-N (APN). (B) Injection (500 nM) over immobilized B. mori cadherin-like protein.