Figure 1.

(A) Domain organization of the M. brevicollis RTKB2 kinase [10]. List of domain abbreviations: Cys, cysteine-rich region; HYR, repeats similar to hyalin domains; SCR, short consensus repeat/complement control protein domain; E, epidermal growth factor repeat; tm, transmembrane sequence; RM2, unique M. brevicollis domain. (B) Amino acid sequence of the RTKB2 kinase domain, aligned with human fibroblast growth factor receptor 1 (FGFR1) and epidermal growth factor receptor (EGFR). Sequences were aligned using the ClustalW program [15] and formatted with BOXSHADE (version 3.21, written by K. Hofmann and M. Baron). The position of the kinase-conserved DFG motif at the beginning of the activation loop is indicated with a red bracket, and an asterisk indicates the position of the potential autophosphorylation site.