Figure 4.

General model illustrating the overlap between regions necessary for folding and regions required for protein-protein interaction. If the overlap between folding and interaction regions is high, the probability to isolate substitutions impairing protein-protein interaction without preventing folding may be high (A), low (B) or very low (C).

Nkengfac et al. BMC Biochemistry 2012 13:16   doi:10.1186/1471-2091-13-16
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