Open Access Highly Accessed Research article

Structural analysis of Brucella abortus RicA substitutions that do not impair interaction with human Rab2 GTPase

Bernard Nkengfac13, Jenny Pouyez2, Emilie Bauwens1, Jean Vandenhaute1, Jean-Jacques Letesson1, Johan Wouters2 and Xavier De Bolle1*

Author Affiliations

1 Molecular Biology Research Unit (URBM), Narilis, University of Namur, 61 Rue Bruxelles, Namur, B-5000, Belgium

2 Laboratory of Structural Biological Chemistry (CBS), member of Narilis, University of Namur, 61 Rue Bruxelles, Namur, B-5000, Belgium

3 Current address: McGill University, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Ave. W., Room L3.05, Montreal, H3A 1A1, Canada

For all author emails, please log on.

BMC Biochemistry 2012, 13:16  doi:10.1186/1471-2091-13-16

Published: 14 August 2012

Additional files

Additional file 1:

Movie S1. Is showing the 3D structure of the RicA trimer model. The color code is the same as Figures 2 and 3. The movement (120°) around the Y axis allows the distinction of zones free of substitutions (in grey). A ribbon is shown for one monomer, by transparency.

Format: MOV Size: 13.4MB Download file

Playing the movie within this page requires QuickTime and JavaScript. Read more

Open Data

Additional file 2:

Movie S2. Is showing the 3D structure of the RicA trimer model. The color code is the same as Figures 2 and 3. The movement (120°) around the X axis allows the distinction of zones free of substitutions (in grey). A ribbon is shown for one monomer, by transparency.

Format: MOV Size: 13.6MB Download file

Playing the movie within this page requires QuickTime and JavaScript. Read more

Open Data

Additional file 3:

Movie S3. Is showing the 3D structure of the RicA monomer model. The color code is the same as Figures 2 and 3. The movement (360°) around the Y axis allows the distinction of zones free of substitutions (in grey). The Cα trace is shown by transparency.

Format: MOV Size: 15.3MB Download file

Playing the movie within this page requires QuickTime and JavaScript. Read more

Open Data

Additional file 4:

Figure S1. Is a multiple sequence alignment of RicA with 17 homologs. Figure S2 shows the exposed loop corresponding to IGFP in RicA homologs of known structure.

Format: DOCX Size: 2.3MB Download file

Open Data