Binding of wild type HP1ß and its E23A variant to Celluspots arrays showing similar binding specificity. Highlighted are some of the spots which carry H3K9me2 and H3R8me2s, some of them together with other modifications. The E23A variant binds better to these spots indicating that the negative effect of H3R8me2s on binding of H3K9me2 is reduced by the E23A mutation.
Bock et al. BMC Biochemistry 2011 12:48 doi:10.1186/1471-2091-12-48