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Current Opinion in Drug Discovery & Development
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| | Current Opinion in Drug Discovery & Development, Volume 6 | |
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   Paper alert J Hirst, P Norman, DP Rotella Current Opinion in Drug Discovery & Development 2003, 6:1-20 (16 January 2003) [PDF] Patent alert
   Patent alert B Swords Current Opinion in Drug Discovery & Development 2003, 6:21-36 (16 January 2003) [PDF] Web alert
   Web alert D Cavalla Current Opinion in Drug Discovery & Development 2003, 6:37-38 (16 January 2003) [PDF] [PubMed] [Related articles] Editorial overview
   Use of microdosing to probe pharmacokinetics in humans - Is it too much for too little? DA Smith, DE Johnson, BK Park Current Opinion in Drug Discovery & Development 2003, 6:39-40 (16 January 2003) [PDF] Review
   Genomic biomarkers of toxicity. FM Goodsaid Current Opinion in Drug Discovery & Development 2003, 6:41-49 (16 January 2003) [PDF] [PubMed] [Related articles] Review
   Evaluation of the toxicological relevance of CYP3A4 induction. NJ Plant, GG Gibson Current Opinion in Drug Discovery & Development 2003, 6:50-56 (16 January 2003) [PDF] [PubMed] [Related articles] Review
   Metabolite identification in drug discovery. AP Watt, RJ Mortshire-Smith, U Gerhard, SR Thomas Current Opinion in Drug Discovery & Development 2003, 6:57-65 (16 January 2003) [PDF] [PubMed] [Related articles] Review
   Drug metabolism and pharmacokinetics in drug discovery. SA Roberts Current Opinion in Drug Discovery & Development 2003, 6:66-80 (16 January 2003) [PDF] [PubMed] [Related articles] Review
   Disease-related determinants of susceptibility to drug-induced idiosyncratic hepatotoxicity. UA Boelsterli Current Opinion in Drug Discovery & Development 2003, 6:81-91 (16 January 2003) [PDF] [PubMed] [Related articles] Review
   New insights into the pharmacological and toxicological effects of thalidomide. C Meierhofer, CJ Wiedermann Current Opinion in Drug Discovery & Development 2003, 6:92-99 (16 January 2003) [PDF] [PubMed] [Related articles] Review
   In vitro hematotoxicity testing in drug development: A review of past, present and future applications. IN Rich Current Opinion in Drug Discovery & Development 2003, 6:100-109 (16 January 2003) [PDF] [PubMed] [Related articles] Review
   New understanding in cardiotoxicity. YJ King Current Opinion in Drug Discovery & Development 2003, 6:110-116 (16 January 2003) [PDF] [PubMed] [Related articles] Review
   Informatics and multivariate analysis of toxicogenomics data. AH Salter, KC Nilsson Current Opinion in Drug Discovery & Development 2003, 6:117-122 (16 January 2003) [PDF] [PubMed] [Related articles] Review
   Role of predictive metabolism and toxicity modeling in drug discovery - A summary of some recent advancements. AG Wilson, AC White, RA Mueller Current Opinion in Drug Discovery & Development 2003, 6:123-128 (16 January 2003) [PDF] [PubMed] [Related articles] Paper alert
   Paper alert J Hirst, P Norman, DP Rotella Current Opinion in Drug Discovery & Development 2003, 6:129-143 (6 March 2003) [PDF] Patent alert
   Patent alert S Wan Current Opinion in Drug Discovery & Development 2003, 6:144-156 (6 March 2003) [PDF] Web alert
   The chemistry of biological products D Cavalla Current Opinion in Drug Discovery & Development 2003, 6:157-158 (6 March 2003) [PDF] [PubMed] [Related articles] Review
   Poxviruses as vectors for cancer immunotherapy H Kwak, H Horig, HL Kaufman Current Opinion in Drug Discovery & Development 2003, 6:161-168 (6 March 2003) [PDF] [PubMed] [Related articles] Review
   Development of vaccines against self-antigens: The p53 paradigm S Chada, A Mhashilkar, JA Roth, D Gabrilovich Current Opinion in Drug Discovery & Development 2003, 6:169-173 (6 March 2003) [PDF] [PubMed] [Related articles] Review
   Recombinant adeno-associated virus: Formulation challenges and strategies for a gene therapy vector JF Wright, G Qu, C Tang, JM Sommer Current Opinion in Drug Discovery & Development 2003, 6:174-178 (6 March 2003) [PDF] [PubMed] [Related articles] [Cited on BioMed Central] Review
   Therapeutic activation of caspases in cancer: A question of selectivity P Beauparlant, GC Shore Current Opinion in Drug Discovery & Development 2003, 6:179-187 (6 March 2003) [PDF] [PubMed] [Related articles] Review
   Production of antibodies and antibody fragments in Escherichia coli and a comparison of their functions, uses and modification DP Humphreys Current Opinion in Drug Discovery & Development 2003, 6:188-196 (6 March 2003) [PDF] [PubMed] [Related articles] Review
   Antibody-based technologies for target discovery RPC Valle, M Jendoubi Current Opinion in Drug Discovery & Development 2003, 6:197-203 (6 March 2003) [PDF] [PubMed] [Related articles] Review
   Recent advances in the development of immunostimulatory oligonucleotides E Uhlmann, J Vollmer Current Opinion in Drug Discovery & Development 2003, 6:204-217 (6 March 2003) [PDF] [PubMed] [Related articles] Review
   Zebrafish: From disease modeling to drug discovery AL Rubinstein Current Opinion in Drug Discovery & Development 2003, 6:218-223 (6 March 2003) [PDF] [PubMed] [Related articles] Review
   Nuclear hormone receptor assays for drug discovery J Rosen, K Marschke, D Rungta Current Opinion in Drug Discovery & Development 2003, 6:224-230 (6 March 2003) [PDF] [PubMed] [Related articles] Review
   Global gene expression analysis of single cells F Kamme, MG Erlander Current Opinion in Drug Discovery & Development 2003, 6:231-236 (6 March 2003) [PDF] [PubMed] [Related articles] Review
   In-depth mutation and SNP discovery using DHPLC gene scanning SL Lilleberg Current Opinion in Drug Discovery & Development 2003, 6:237-252 (6 March 2003) [PDF] [PubMed] [Related articles] Review
   Toward third-generation aptamers: Spiegelmers and their therapeutic prospects A Vater, S Klussmann Current Opinion in Drug Discovery & Development 2003, 6:253-261 (6 March 2003) [PDF] [PubMed] [Related articles] Review
   Direct methods to determine protein function LL Ilag Current Opinion in Drug Discovery & Development 2003, 6:262-268 (6 March 2003) [PDF] [PubMed] [Related articles] Paper alert
   Paper alert J Hirst, P Norman Current Opinion in Drug Discovery & Development 2003, 6:269-282 (20 May 2003) [PDF] Patent alert
   Patent alert S Wan Current Opinion in Drug Discovery & Development 2003, 6:283-293 (20 May 2003) [PDF] Web alert
   Web alert D Cavalla Current Opinion in Drug Discovery & Development 2003, 6:294-295 (20 May 2003) [PDF] [PubMed] [Related articles] Editorial overview
   Mining the genome for gems. P Gund, E Maliski, F Brown Current Opinion in Drug Discovery & Development 2003, 6:296 (20 May 2003) [PDF] Review
   Genetic sequence data for pharmacogenomics. RB Altman Current Opinion in Drug Discovery & Development 2003, 6:297-303 (20 May 2003) [PDF] [PubMed] [Related articles] Review
   Genome-wide prediction of disease-relevant genes and variants. J Freudenberg Current Opinion in Drug Discovery & Development 2003, 6:304-309 (20 May 2003) [PDF] [PubMed] [Related articles] Review
   Prioritizing the human genome: Knowledge management for drug discovery. JB Golden Current Opinion in Drug Discovery & Development 2003, 6:310-316 (20 May 2003) [PDF] [PubMed] [Related articles] Review
   High-throughput SNP analysis for genetic association studies. G Marnellos Current Opinion in Drug Discovery & Development 2003, 6:317-321 (20 May 2003) [PDF] [PubMed] [Related articles] [Cited on BioMed Central] Review
   Proteomic informatics: In silico methods lead to data management challenges. D Haley-Vicente, DJ Edwards Current Opinion in Drug Discovery & Development 2003, 6:322-332 (20 May 2003) [PDF] [PubMed] [Related articles] Review
   Tools for discovery: Gene expression enterprise solutions. A Grewal, J Stockton, C Bolger Current Opinion in Drug Discovery & Development 2003, 6:333-338 (20 May 2003) [PDF] [PubMed] [Related articles] Review
   Algorithms for high-density oligonucleotide array. Y Zhou, R Abagyan Current Opinion in Drug Discovery & Development 2003, 6:339-345 (20 May 2003) [PDF] [PubMed] [Related articles] [Cited on BioMed Central] Review
   Integration of data and methods for genome analysis. P Durand, C Medigue, A Morgat, Y Vandenbrouck, A Viari, F Rechenmann Current Opinion in Drug Discovery & Development 2003, 6:346-352 (20 May 2003) [PDF] [PubMed] [Related articles] [Cited on BioMed Central] Review
   Modeling the 3D structure of GPCRs: Advances and application to drug discovery. OM Becker, S Shacham, Y Marantz, S Noiman Current Opinion in Drug Discovery & Development 2003, 6:353-361 (20 May 2003) [PDF] [PubMed] [Related articles] [Cited on BioMed Central] Review
   The use of electronic reaction databases in process chemistry. DM Gange, J D'Antuono Current Opinion in Drug Discovery & Development 2003, 6:362-369 (20 May 2003) [PDF] [PubMed] [Related articles] Review
   Chemical feature-based pharmacophores and virtual library screening for discovery of new leads. T Langer, EM Krovat Current Opinion in Drug Discovery & Development 2003, 6:370-376 (20 May 2003) [PDF] [PubMed] [Related articles] Review
   Enabling high-throughput discovery. M Vaschetto, T Weissbrod, D Bodle, O Guner Current Opinion in Drug Discovery & Development 2003, 6:377-383 (20 May 2003) [PDF] [PubMed] [Related articles] Review
   Microarray expression profiling: Analysis and applications. Z Xiang, Y Yang, X Ma, W Ding Current Opinion in Drug Discovery & Development 2003, 6:384-395 (20 May 2003) [PDF] [PubMed] [Related articles] [Cited on BioMed Central] Review
   Databases and data mining for computational vaccinology. DR Flower Current Opinion in Drug Discovery & Development 2003, 6:396-400 (20 May 2003) [PDF] [PubMed] [Related articles] Paper alert
   Paper alert J Hirst, P Norman, DP Rotella Current Opinion in Drug Discovery & Development 2003, 6:401-419 (23 July 2003) [PDF] Patent alert
   Patent alert S Wan Current Opinion in Drug Discovery & Development 2003, 6:420-431 (23 July 2003) [PDF] Web alert
   The chemistry of drug design and lead optimization D Cavalla Current Opinion in Drug Discovery & Development 2003, 6:432-433 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   Letter to the Editor D Rognan Current Opinion in Drug Discovery & Development 2003, 6:434 (23 July 2003) [PDF] [PubMed] [Related articles] Editorial overview
   The chemistry of drug design and lead optimization W Greenlee, M Desai Current Opinion in Drug Discovery & Development 2003, 6:435-436 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   Structure-based design of thrombin inhibitors R Pfau Current Opinion in Drug Discovery & Development 2003, 6:437-450 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   Inhibitors of the entry of HIV into host cells NA Meanwell, JF Kadow Current Opinion in Drug Discovery & Development 2003, 6:451-461 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   HTS techniques to investigate the potential effects of compounds on cardiac ion channels at early-stages of drug discovery R Netzer, U Bischoff, A Ebneth Current Opinion in Drug Discovery & Development 2003, 6:462-469 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   Predicting ADME properties and side effects: The BioPrint approach CM Krejsa, D Horvath, SL Rogalski, JE Penzotti, B Mao, F Barbosa, JC Migeon Current Opinion in Drug Discovery & Development 2003, 6:470-480 (23 July 2003) [PDF] [PubMed] [Related articles] [F1000 Biology] Review
   Lead optimization strategies as part of a drug metabolism environment WA Korfmacher Current Opinion in Drug Discovery & Development 2003, 6:481-485 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   The role of flavin-containing monooxygenases in drug metabolism and development JR Cashman Current Opinion in Drug Discovery & Development 2003, 6:486-493 (23 July 2003) [PDF] [PubMed] [Related articles] [Cited on BioMed Central] Review
   The impact of combinatorial chemistry on drug discovery A Lee, JG Breitenbucher Current Opinion in Drug Discovery & Development 2003, 6:494-508 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   Dynamic combinatorial chemistry: A new method for selection and preparation of synthetic receptors S Otto Current Opinion in Drug Discovery & Development 2003, 6:509-520 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   Recent advances in automated solid-phase carbohydrate synthesis: From screening to vaccines OJ Plante, PH Seeberger Current Opinion in Drug Discovery & Development 2003, 6:521-525 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   Silicon chemistry as a novel source of chemical diversity in drug design W Bains, R Tacke Current Opinion in Drug Discovery & Development 2003, 6:526-543 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   Crystallography, NMR and virtual screening: Integrated tools for drug discovery SW Muchmore, PJ Hajduk Current Opinion in Drug Discovery & Development 2003, 6:544-549 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   The importance of characterizing the crystal form of the drug substance during drug development SD Clas Current Opinion in Drug Discovery & Development 2003, 6:550-560 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   Antisense and RNAi: Powerful tools in drug target discovery and validation KS Lavery, TH King Current Opinion in Drug Discovery & Development 2003, 6:561-569 (23 July 2003) [PDF] [PubMed] [Related articles] Review
   Human cell systems for drug discovery C Horrocks, R Halse, R Suzuki, PR Shepherd Current Opinion in Drug Discovery & Development 2003, 6:570-575 (23 July 2003) [PDF] [PubMed] [Related articles] Paper alert
   Paper alert J Hirst, P Norman, D Rotella Current Opinion in Drug Discovery & Development 2003, 6:577-594 (23 September 2003) [PDF] Patent alert
   Patent alert S Wan Current Opinion in Drug Discovery & Development 2003, 6:595-606 (23 September 2003) [PDF] Web alert
   Web alert D Cavalla Current Opinion in Drug Discovery & Development 2003, 6:607-608 (23 September 2003) [PDF] [PubMed] [Related articles] Editorial overview
   Editorial overview JA Lowe, CH Hill, M Duckworth Current Opinion in Drug Discovery & Development 2003, 6:609-610 (23 September 2003) [PDF] Review
   Ion channel structures: A review of recent progress C Domene, S Haider, MSP Sansom Current Opinion in Drug Discovery & Development 2003, 6:611-619 (23 September 2003) [PDF] [PubMed] [Related articles] Review
   Modulation of nicotinic acetylcholine receptor function through the outer and middle rings of transmembrane domains FJ Barrantes Current Opinion in Drug Discovery & Development 2003, 6:620-632 (23 September 2003) [PDF] [PubMed] [Related articles] [Cited on BioMed Central] Review
   Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action HA Lester, C Fonck, AR Tapper, S McKinney, MI Damaj, S Balogh, J Owens, JM Wehner, AC Collins, C Labarca Current Opinion in Drug Discovery & Development 2003, 6:633-639 (23 September 2003) [PDF] [PubMed] [Related articles] Review
   Potassium channels as therapeutic targets for autoimmune disorders H Wulff, C Beeton, KG Chandy Current Opinion in Drug Discovery & Development 2003, 6:640-647 (23 September 2003) [PDF] [PubMed] [Related articles] Review
   The GABAA receptor gene family: New opportunities for drug development PJ Whiting Current Opinion in Drug Discovery & Development 2003, 6:648-657 (23 September 2003) [PDF] [PubMed] [Related articles] [Cited on BioMed Central] Review
   The role of nitric oxide in the physiological regulation of Ca2+ cycling SA Khan, JM Hare Current Opinion in Drug Discovery & Development 2003, 6:658-666 (23 September 2003) [PDF] [PubMed] [Related articles] Review
   Molecular determinants of high-affinity drug binding to HERG channels JS Mitcheson, MD Perry Current Opinion in Drug Discovery & Development 2003, 6:667-674 (23 September 2003) [PDF] [PubMed] [Related articles] Review
   Glycine transporter isoforms in the mammalian central nervous system: Structures, functions and therapeutic promises J Gomeza, K Ohno, H Betz Current Opinion in Drug Discovery & Development 2003, 6:675-682 (23 September 2003) [PDF] [PubMed] [Related articles] Review
   Blood-brain barrier genomics and the use of endogenous transporters to cause drug penetration into the brain WM Pardridge Current Opinion in Drug Discovery & Development 2003, 6:683-691 (23 September 2003) [PDF] [PubMed] [Related articles] Review
   Nuclear hormone receptor co-regulators OY Khan, Z Nawaz Current Opinion in Drug Discovery & Development 2003, 6:692-701 (23 September 2003) [PDF] [PubMed] [Related articles] Review
   Androgen receptor and prostate cancer: Molecular aspects and gene expression profiling A Sommer, B Haendler Current Opinion in Drug Discovery & Development 2003, 6:702-711 (23 September 2003) [PDF] [PubMed] [Related articles] Review
   Prospects of memory-modifying drugs that target the CREB pathway T Jackson, M Ramaswami Current Opinion in Drug Discovery & Development 2003, 6:712-719 (23 September 2003) [PDF] [PubMed] [Related articles] Review
   Targeting IkappaB kinase for the treatment of inflammatory and other disorders JR Burke Current Opinion in Drug Discovery & Development 2003, 6:720-728 (23 September 2003) [PDF] [PubMed] [Related articles] [Cited on BioMed Central] Review
   Novel bone-targeted Src tyrosine kinase inhibitor drug discovery
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