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Current Opinion in Drug Discovery & Development
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| | Current Opinion in Drug Discovery & Development, Volume 6 |
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Paper alert
J Hirst, P Norman, DP Rotella
Current Opinion in Drug Discovery & Development 2003, 6:1-20 (16January2003)
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Patent alert
Patent alert
B Swords
Current Opinion in Drug Discovery & Development 2003, 6:21-36 (16January2003)
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Web alert
Web alert
D Cavalla
Current Opinion in Drug Discovery & Development 2003, 6:37-38 (16January2003)
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Editorial overview
Use of microdosing to probe pharmacokinetics in humans - Is it too much for too little?
DA Smith, DE Johnson, BK Park
Current Opinion in Drug Discovery & Development 2003, 6:39-40 (16January2003)
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Review
Genomic biomarkers of toxicity.
FM Goodsaid
Current Opinion in Drug Discovery & Development 2003, 6:41-49 (16January2003)
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Review
Evaluation of the toxicological relevance of CYP3A4 induction.
NJ Plant, GG Gibson
Current Opinion in Drug Discovery & Development 2003, 6:50-56 (16January2003)
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Review
Metabolite identification in drug discovery.
AP Watt, RJ Mortshire-Smith, U Gerhard, SR Thomas
Current Opinion in Drug Discovery & Development 2003, 6:57-65 (16January2003)
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Review
Drug metabolism and pharmacokinetics in drug discovery.
SA Roberts
Current Opinion in Drug Discovery & Development 2003, 6:66-80 (16January2003)
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Review
Disease-related determinants of susceptibility to drug-induced idiosyncratic hepatotoxicity.
UA Boelsterli
Current Opinion in Drug Discovery & Development 2003, 6:81-91 (16January2003)
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Review
New insights into the pharmacological and toxicological effects of thalidomide.
C Meierhofer, CJ Wiedermann
Current Opinion in Drug Discovery & Development 2003, 6:92-99 (16January2003)
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Review
In vitro hematotoxicity testing in drug development: A review of past, present and future applications.
IN Rich
Current Opinion in Drug Discovery & Development 2003, 6:100-109 (16January2003)
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Review
New understanding in cardiotoxicity.
YJ King
Current Opinion in Drug Discovery & Development 2003, 6:110-116 (16January2003)
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Review
Informatics and multivariate analysis of toxicogenomics data.
AH Salter, KC Nilsson
Current Opinion in Drug Discovery & Development 2003, 6:117-122 (16January2003)
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Review
Role of predictive metabolism and toxicity modeling in drug discovery - A summary of some recent advancements.
AG Wilson, AC White, RA Mueller
Current Opinion in Drug Discovery & Development 2003, 6:123-128 (16January2003)
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Paper alert
Paper alert
J Hirst, P Norman, DP Rotella
Current Opinion in Drug Discovery & Development 2003, 6:129-143 (6March2003)
[PDF]
Patent alert
Patent alert
S Wan
Current Opinion in Drug Discovery & Development 2003, 6:144-156 (6March2003)
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Web alert
The chemistry of biological products
D Cavalla
Current Opinion in Drug Discovery & Development 2003, 6:157-158 (6March2003)
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Review
Poxviruses as vectors for cancer immunotherapy
H Kwak, H Horig, HL Kaufman
Current Opinion in Drug Discovery & Development 2003, 6:161-168 (6March2003)
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Review
Development of vaccines against self-antigens: The p53 paradigm
S Chada, A Mhashilkar, JA Roth, D Gabrilovich
Current Opinion in Drug Discovery & Development 2003, 6:169-173 (6March2003)
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Review
Recombinant adeno-associated virus: Formulation challenges and strategies for a gene therapy vector
JF Wright, G Qu, C Tang, JM Sommer
Current Opinion in Drug Discovery & Development 2003, 6:174-178 (6March2003)
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Review
Therapeutic activation of caspases in cancer: A question of selectivity
P Beauparlant, GC Shore
Current Opinion in Drug Discovery & Development 2003, 6:179-187 (6March2003)
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Review
Production of antibodies and antibody fragments in Escherichia coli and a comparison of their functions, uses and modification
DP Humphreys
Current Opinion in Drug Discovery & Development 2003, 6:188-196 (6March2003)
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Review
Antibody-based technologies for target discovery
RPC Valle, M Jendoubi
Current Opinion in Drug Discovery & Development 2003, 6:197-203 (6March2003)
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Review
Recent advances in the development of immunostimulatory oligonucleotides
E Uhlmann, J Vollmer
Current Opinion in Drug Discovery & Development 2003, 6:204-217 (6March2003)
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Review
Zebrafish: From disease modeling to drug discovery
AL Rubinstein
Current Opinion in Drug Discovery & Development 2003, 6:218-223 (6March2003)
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Review
Nuclear hormone receptor assays for drug discovery
J Rosen, K Marschke, D Rungta
Current Opinion in Drug Discovery & Development 2003, 6:224-230 (6March2003)
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Review
Global gene expression analysis of single cells
F Kamme, MG Erlander
Current Opinion in Drug Discovery & Development 2003, 6:231-236 (6March2003)
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Review
In-depth mutation and SNP discovery using DHPLC gene scanning
SL Lilleberg
Current Opinion in Drug Discovery & Development 2003, 6:237-252 (6March2003)
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Review
Toward third-generation aptamers: Spiegelmers and their therapeutic prospects
A Vater, S Klussmann
Current Opinion in Drug Discovery & Development 2003, 6:253-261 (6March2003)
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Review
Direct methods to determine protein function
LL Ilag
Current Opinion in Drug Discovery & Development 2003, 6:262-268 (6March2003)
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Paper alert
Paper alert
J Hirst, P Norman
Current Opinion in Drug Discovery & Development 2003, 6:269-282 (20May2003)
[PDF]
Patent alert
Patent alert
S Wan
Current Opinion in Drug Discovery & Development 2003, 6:283-293 (20May2003)
[PDF]
Web alert
Web alert
D Cavalla
Current Opinion in Drug Discovery & Development 2003, 6:294-295 (20May2003)
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Editorial overview
Mining the genome for gems.
P Gund, E Maliski, F Brown
Current Opinion in Drug Discovery & Development 2003, 6:296 (20May2003)
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Review
Genetic sequence data for pharmacogenomics.
RB Altman
Current Opinion in Drug Discovery & Development 2003, 6:297-303 (20May2003)
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Review
Genome-wide prediction of disease-relevant genes and variants.
J Freudenberg
Current Opinion in Drug Discovery & Development 2003, 6:304-309 (20May2003)
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Review
Prioritizing the human genome: Knowledge management for drug discovery.
JB Golden
Current Opinion in Drug Discovery & Development 2003, 6:310-316 (20May2003)
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Review
High-throughput SNP analysis for genetic association studies.
G Marnellos
Current Opinion in Drug Discovery & Development 2003, 6:317-321 (20May2003)
[PDF] [PubMed] [Related articles] [Cited on BioMed Central]
Review
Proteomic informatics: In silico methods lead to data management challenges.
D Haley-Vicente, DJ Edwards
Current Opinion in Drug Discovery & Development 2003, 6:322-332 (20May2003)
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Review
Tools for discovery: Gene expression enterprise solutions.
A Grewal, J Stockton, C Bolger
Current Opinion in Drug Discovery & Development 2003, 6:333-338 (20May2003)
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Review
Algorithms for high-density oligonucleotide array.
Y Zhou, R Abagyan
Current Opinion in Drug Discovery & Development 2003, 6:339-345 (20May2003)
[PDF] [PubMed] [Related articles] [Cited on BioMed Central]
Review
Integration of data and methods for genome analysis.
P Durand, C Medigue, A Morgat, Y Vandenbrouck, A Viari, F Rechenmann
Current Opinion in Drug Discovery & Development 2003, 6:346-352 (20May2003)
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Review
Modeling the 3D structure of GPCRs: Advances and application to drug discovery.
OM Becker, S Shacham, Y Marantz, S Noiman
Current Opinion in Drug Discovery & Development 2003, 6:353-361 (20May2003)
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Review
The use of electronic reaction databases in process chemistry.
DM Gange, J D'Antuono
Current Opinion in Drug Discovery & Development 2003, 6:362-369 (20May2003)
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Review
Chemical feature-based pharmacophores and virtual library screening for discovery of new leads.
T Langer, EM Krovat
Current Opinion in Drug Discovery & Development 2003, 6:370-376 (20May2003)
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Review
Enabling high-throughput discovery.
M Vaschetto, T Weissbrod, D Bodle, O Guner
Current Opinion in Drug Discovery & Development 2003, 6:377-383 (20May2003)
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Review
Microarray expression profiling: Analysis and applications.
Z Xiang, Y Yang, X Ma, W Ding
Current Opinion in Drug Discovery & Development 2003, 6:384-395 (20May2003)
[PDF] [PubMed] [Related articles] [Cited on BioMed Central]
Review
Databases and data mining for computational vaccinology.
DR Flower
Current Opinion in Drug Discovery & Development 2003, 6:396-400 (20May2003)
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Paper alert
Paper alert
J Hirst, P Norman, DP Rotella
Current Opinion in Drug Discovery & Development 2003, 6:401-419 (23July2003)
[PDF]
Patent alert
Patent alert
S Wan
Current Opinion in Drug Discovery & Development 2003, 6:420-431 (23July2003)
[PDF]
Web alert
The chemistry of drug design and lead optimization
D Cavalla
Current Opinion in Drug Discovery & Development 2003, 6:432-433 (23July2003)
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Review
Letter to the Editor
D Rognan
Current Opinion in Drug Discovery & Development 2003, 6:434 (23July2003)
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Editorial overview
The chemistry of drug design and lead optimization
W Greenlee, M Desai
Current Opinion in Drug Discovery & Development 2003, 6:435-436 (23July2003)
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Review
Structure-based design of thrombin inhibitors
R Pfau
Current Opinion in Drug Discovery & Development 2003, 6:437-450 (23July2003)
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Review
Inhibitors of the entry of HIV into host cells
NA Meanwell, JF Kadow
Current Opinion in Drug Discovery & Development 2003, 6:451-461 (23July2003)
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Review
HTS techniques to investigate the potential effects of compounds on cardiac ion channels at early-stages of drug discovery
R Netzer, U Bischoff, A Ebneth
Current Opinion in Drug Discovery & Development 2003, 6:462-469 (23July2003)
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Review
Predicting ADME properties and side effects: The BioPrint approach
CM Krejsa, D Horvath, SL Rogalski, JE Penzotti, B Mao, F Barbosa, JC Migeon
Current Opinion in Drug Discovery & Development 2003, 6:470-480 (23July2003)
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Review
Lead optimization strategies as part of a drug metabolism environment
WA Korfmacher
Current Opinion in Drug Discovery & Development 2003, 6:481-485 (23July2003)
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Review
The role of flavin-containing monooxygenases in drug metabolism and development
JR Cashman
Current Opinion in Drug Discovery & Development 2003, 6:486-493 (23July2003)
[PDF] [PubMed] [Related articles] [Cited on BioMed Central]
Review
The impact of combinatorial chemistry on drug discovery
A Lee, JG Breitenbucher
Current Opinion in Drug Discovery & Development 2003, 6:494-508 (23July2003)
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Review
Dynamic combinatorial chemistry: A new method for selection and preparation of synthetic receptors
S Otto
Current Opinion in Drug Discovery & Development 2003, 6:509-520 (23July2003)
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Review
Recent advances in automated solid-phase carbohydrate synthesis: From screening to vaccines
OJ Plante, PH Seeberger
Current Opinion in Drug Discovery & Development 2003, 6:521-525 (23July2003)
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Review
Silicon chemistry as a novel source of chemical diversity in drug design
W Bains, R Tacke
Current Opinion in Drug Discovery & Development 2003, 6:526-543 (23July2003)
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Review
Crystallography, NMR and virtual screening: Integrated tools for drug discovery
SW Muchmore, PJ Hajduk
Current Opinion in Drug Discovery & Development 2003, 6:544-549 (23July2003)
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Review
The importance of characterizing the crystal form of the drug substance during drug development
SD Clas
Current Opinion in Drug Discovery & Development 2003, 6:550-560 (23July2003)
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Review
Antisense and RNAi: Powerful tools in drug target discovery and validation
KS Lavery, TH King
Current Opinion in Drug Discovery & Development 2003, 6:561-569 (23July2003)
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Review
Human cell systems for drug discovery
C Horrocks, R Halse, R Suzuki, PR Shepherd
Current Opinion in Drug Discovery & Development 2003, 6:570-575 (23July2003)
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Paper alert
Paper alert
J Hirst, P Norman, D Rotella
Current Opinion in Drug Discovery & Development 2003, 6:577-594 (23September2003)
[PDF]
Patent alert
Patent alert
S Wan
Current Opinion in Drug Discovery & Development 2003, 6:595-606 (23September2003)
[PDF]
Web alert
Web alert
D Cavalla
Current Opinion in Drug Discovery & Development 2003, 6:607-608 (23September2003)
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Editorial overview
Editorial overview
JA Lowe, CH Hill, M Duckworth
Current Opinion in Drug Discovery & Development 2003, 6:609-610 (23September2003)
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Review
Ion channel structures: A review of recent progress
C Domene, S Haider, MSP Sansom
Current Opinion in Drug Discovery & Development 2003, 6:611-619 (23September2003)
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Review
Modulation of nicotinic acetylcholine receptor function through the outer and middle rings of transmembrane domains
FJ Barrantes
Current Opinion in Drug Discovery & Development 2003, 6:620-632 (23September2003)
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Review
Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action
HA Lester, C Fonck, AR Tapper, S McKinney, MI Damaj, S Balogh, J Owens, JM Wehner, AC Collins, C Labarca
Current Opinion in Drug Discovery & Development 2003, 6:633-639 (23September2003)
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Review
Potassium channels as therapeutic targets for autoimmune disorders
H Wulff, C Beeton, KG Chandy
Current Opinion in Drug Discovery & Development 2003, 6:640-647 (23September2003)
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Review
The GABAA receptor gene family: New opportunities for drug development
PJ Whiting
Current Opinion in Drug Discovery & Development 2003, 6:648-657 (23September2003)
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Review
The role of nitric oxide in the physiological regulation of Ca2+ cycling
SA Khan, JM Hare
Current Opinion in Drug Discovery & Development 2003, 6:658-666 (23September2003)
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Review
Molecular determinants of high-affinity drug binding to HERG channels
JS Mitcheson, MD Perry
Current Opinion in Drug Discovery & Development 2003, 6:667-674 (23September2003)
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Review
Glycine transporter isoforms in the mammalian central nervous system: Structures, functions and therapeutic promises
J Gomeza, K Ohno, H Betz
Current Opinion in Drug Discovery & Development 2003, 6:675-682 (23September2003)
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Review
Blood-brain barrier genomics and the use of endogenous transporters to cause drug penetration into the brain
WM Pardridge
Current Opinion in Drug Discovery & Development 2003, 6:683-691 (23September2003)
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Review
Nuclear hormone receptor co-regulators
OY Khan, Z Nawaz
Current Opinion in Drug Discovery & Development 2003, 6:692-701 (23September2003)
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Review
Androgen receptor and prostate cancer: Molecular aspects and gene expression profiling
A Sommer, B Haendler
Current Opinion in Drug Discovery & Development 2003, 6:702-711 (23September2003)
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Review
Prospects of memory-modifying drugs that target the CREB pathway
T Jackson, M Ramaswami
Current Opinion in Drug Discovery & Development 2003, 6:712-719 (23September2003)
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Review
Targeting IkappaB kinase for the treatment of inflammatory and other disorders
JR Burke
Current Opinion in Drug Discovery & Development 2003, 6:720-728 (23September2003)
[PDF] [PubMed] [Related articles] [Cited on BioMed Central]
Review
Novel bone-targeted Src tyrosine kinase inhibitor drug discovery
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