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Current Opinion in Drug Discovery & Development
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| | Current Opinion in Drug Discovery & Development, Volume 5 |
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Paper alert
J Hirst, P Norman
Current Opinion in Drug Discovery & Development 2002, 5:1-19 (15January2002)
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Patent alert
Patent alert
B Swords
Current Opinion in Drug Discovery & Development 2002, 5:20-28 (15January2002)
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Review
The chemistry of metabolic and toxicological processes
D Cavalla
Current Opinion in Drug Discovery & Development 2002, 5:29-30 (15January2002)
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Editorial overview
The chemistry of metabolic and toxicological processes
DE Johnson, DA Smith, BK Park
Current Opinion in Drug Discovery & Development 2002, 5:31-32 (15January2002)
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Review
High-throughput and in silico techniques in drug metabolism and pharmacokinetics
H van de Waterbeemd
Current Opinion in Drug Discovery & Development 2002, 5:33-43 (15January2002)
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Review
Evolutionary computational methods to predict oral bioavailability QSPRs
W Bains, R Gilbert, L Sviridenko, JM Gascon, R Scoffin, K Birchall, I Harvey, J Caldwell
Current Opinion in Drug Discovery & Development 2002, 5:44-51 (15January2002)
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Review
Automated sample preparation and LC-MS for high-throughput ADME quantification
D O'Connor
Current Opinion in Drug Discovery & Development 2002, 5:52-58 (15January2002)
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Review
Intravenous administration of poorly soluble new drug entities in early drug discovery: The potential impact of formulation on pharmacokinetic parameters
B Bittner, RJ Mountfield
Current Opinion in Drug Discovery & Development 2002, 5:59-71 (15January2002)
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Review
Increasing throughput in lead optimization in vivo toxicity screens
V Meador, W Jordan, J Zimmermann
Current Opinion in Drug Discovery & Development 2002, 5:72-78 (15January2002)
[PDF] [PubMed] [Related articles]
Review
Gene expression profiling for pharmaceutical toxicology screening
PJ Bugelski
Current Opinion in Drug Discovery & Development 2002, 5:79-89 (15January2002)
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Review
Transcriptomics in predictive toxicology
T Storck, Brevern MC von, CK Behrens, J Scheel, A Bach
Current Opinion in Drug Discovery & Development 2002, 5:90-97 (15January2002)
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Review
Analysis of gene and protein expression for drug mode of toxicity
LM Furness
Current Opinion in Drug Discovery & Development 2002, 5:98-103 (15January2002)
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Review
Toxicophores: Groups and metabolic routes associated with increased safety risk
DP Williams, DJ Naisbitt
Current Opinion in Drug Discovery & Development 2002, 5:104-115 (15January2002)
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Review
Towards a drug concentration effect relationship for QT prolongation and torsades de pointes
R Webster, D Leishman, D Walker
Current Opinion in Drug Discovery & Development 2002, 5:116-126 (15January2002)
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Review
Models for profiling the potential QT prolongation risk of drugs
AL Muzikant, RC Penland
Current Opinion in Drug Discovery & Development 2002, 5:127-135 (15January2002)
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Review
Improving structure-linked access to publicly available chemical toxicity information
AM Richard, CR Williams, NF Cariello
Current Opinion in Drug Discovery & Development 2002, 5:136-143 (15January2002)
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Review
Genotype/phenotype comparisons: A probe for the effect of disease progression on drug metabolism
ML Williams, IW Wainer
Current Opinion in Drug Discovery & Development 2002, 5:144-149 (15January2002)
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Review
Structural insights into the promiscuity and function of the human pregnane X receptor
RE Watkins, SM Noble, MR Redinbo
Current Opinion in Drug Discovery & Development 2002, 5:150 (15January2002)
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Paper alert
Paper alert
J Hirst, P Norman, DP Rotella
Current Opinion in Drug Discovery & Development 2002, 5:159-177 (12March2002)
[PDF]
Patent alert
Patent alert
B Swords
Current Opinion in Drug Discovery & Development 2002, 5:178-188 (12March2002)
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Web alert
The chemistry of biological products.
D Cavalla
Current Opinion in Drug Discovery & Development 2002, 5:189-190 (12March2002)
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Editorial overview
The chemistry of biological processes.
J McAlpine, K Culver, D Ecker
Current Opinion in Drug Discovery & Development 2002, 5:191-193 (12March2002)
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Review
Live bacteria as anticancer agents and tumor-selective protein delivery vectors.
D Bermudes, L Zheng, IC King
Current Opinion in Drug Discovery & Development 2002, 5:194-199 (12March2002)
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Review
The genus Bifidobacterium for cancer gene therapy.
M Fujimori, J Amano, S Taniguchi
Current Opinion in Drug Discovery & Development 2002, 5:200-203 (12March2002)
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Review
Recombinant antibodies for the selective targeting of tumor neovasculature.
F Viti, L Giovannoni, D Neri
Current Opinion in Drug Discovery & Development 2002, 5:204-213 (12March2002)
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Review
Inhibitors of growth factor receptor kinase-dependent signaling pathways in anticancer chemotherapy - clinical progress.
P Renhowe
Current Opinion in Drug Discovery & Development 2002, 5:214-224 (12March2002)
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Review
Current progress on farnesyl protein transferase inhibitors.
SB Singh, RB Lingham
Current Opinion in Drug Discovery & Development 2002, 5:225-244 (12March2002)
[PDF] [PubMed] [Related articles] [Cited on BioMed Central]
Review
Recent developments in peptide-based cancer therapeutics.
A Sehgal
Current Opinion in Drug Discovery & Development 2002, 5:245-250 (12March2002)
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Review
The cyclotides: Novel macrocyclic peptides as scaffolds in drug design.
DJ Craik, S Simonsen, NL Daly
Current Opinion in Drug Discovery & Development 2002, 5:251-260 (12March2002)
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Review
Therapeutic applications of guanylate cyclase-C receptor agonists.
K Shailubhai
Current Opinion in Drug Discovery & Development 2002, 5:261-268 (12March2002)
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Review
Bacterial toxins as versatile delivery vehicles.
L deHaan, TR Hirst
Current Opinion in Drug Discovery & Development 2002, 5:269-278 (12March2002)
[PDF] [PubMed] [Related articles]
Review
Drug delivery systems based on sugar-macromolecule conjugates.
BG Davis, MA Robinson
Current Opinion in Drug Discovery & Development 2002, 5:279-288 (12March2002)
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Review
Use of HSV vectors to modify the nervous system.
JC Glorioso, DJ Fink
Current Opinion in Drug Discovery & Development 2002, 5:289-295 (12March2002)
[PDF] [PubMed] [Related articles] [Cited on BioMed Central]
Review
Plant cell cultures as a source of bioactive small molecules.
AM Stafford
Current Opinion in Drug Discovery & Development 2002, 5:296-303 (12March2002)
[PDF] [PubMed] [Related articles]
Review
Mother nature's combinatorial libraries; their influence on the synthesis of drugs.
DGI Kingston, DJ Newman
Current Opinion in Drug Discovery & Development 2002, 5:304-316 (12March2002)
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Review
Erratum: William Bains, Richard Gilbert, Lilya Sviridenko, Jose-Miguel Gascon, Robert Scoffin, Kris Birchall, Lesley Hetherington, Inman Harvey & John Caldwell: Evolutionary computational methods to predict oral bioavailability QSPRs. Curr Opin Drug Discovery Dev (2002) 5(1):44-51.
Current Opinion in Drug Discovery & Development 2002, 5:317 (12March2002)
[PDF]
Paper alert
Paper alert
J Hirst, P Norman, DP Rotella
Current Opinion in Drug Discovery & Development 2002, 5:319-338 (14May2002)
[PDF]
Patent alert
Patent alert
B Swords
Current Opinion in Drug Discovery & Development 2002, 5:339-351 (14May2002)
[PDF]
Web alert
The management of chemical and biological information
D Cavalla
Current Opinion in Drug Discovery & Development 2002, 5:352-353 (14May2002)
[PDF] [PubMed] [Related articles]
Editorial overview
Discovery systems integration: Is it strategic or tactical?
P Gund, F Brown, E Maliski
Current Opinion in Drug Discovery & Development 2002, 5:354 (14May2002)
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Review
Global analysis of large-scale chemical and biological experiments
DE Root, BP Kelley, BR Stockwell
Current Opinion in Drug Discovery & Development 2002, 5:355-360 (14May2002)
[PDF] [PubMed] [Related articles]
Review
Component architecture in drug discovery informatics
PM Smith
Current Opinion in Drug Discovery & Development 2002, 5:361-366 (14May2002)
[PDF] [PubMed] [Related articles]
Review
Structural genomics: Bridging functional genomics and structure-based drug design
SG Buchanan
Current Opinion in Drug Discovery & Development 2002, 5:367-381 (14May2002)
[PDF] [PubMed] [Related articles]
Review
Progress in computational methods for the prediction of ADMET properties
DE Clark, PDJ Grootenhuis
Current Opinion in Drug Discovery & Development 2002, 5:382-390 (14May2002)
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Review
Fragment analysis in small molecule discovery
C Meriot, D Domine, DJ Church
Current Opinion in Drug Discovery & Development 2002, 5:391-399 (14May2002)
[PDF] [PubMed] [Related articles]
Review
Knowledge-based approaches in the design and selection of compound libraries for drug discovery
VN Viswanadhan, C Balan, C Hulme, JC Cheetham, Y Sun
Current Opinion in Drug Discovery & Development 2002, 5:400-406 (14May2002)
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Review
Structure-based approaches to drug design and virtual screening
B Waszkowycz
Current Opinion in Drug Discovery & Development 2002, 5:407-413 (14May2002)
[PDF] [PubMed] [Related articles]
Review
High-throughput virtual screening for drug discovery in parallel
LM Toledo-Sherman, D Chen
Current Opinion in Drug Discovery & Development 2002, 5:414-421 (14May2002)
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Review
Initial compound selection for sequential screening
SS Young, RLH Lam, WJ Welch
Current Opinion in Drug Discovery & Development 2002, 5:422-427 (14May2002)
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Review
Multiscale and Bayesian approaches to data analysis in genomics high- throughput screening
C Yang, BR Bakshi, JF Rathman, PE Blower
Current Opinion in Drug Discovery & Development 2002, 5:428-438 (14May2002)
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Paper alert
Paper alert
J Hirst, P Norman, DP Rotella
Current Opinion in Drug Discovery & Development 2002, 5:439-458 (31July2002)
[PDF]
Patent alert
Patent alert
B Swords
Current Opinion in Drug Discovery & Development 2002, 5:459-472 (31July2002)
[PDF]
Web alert
Web alert
D Cavalla
Current Opinion in Drug Discovery & Development 2002, 5:473-474 (31July2002)
[PDF] [PubMed] [Related articles]
Editorial overview
Chemical genomics, pharmacogenomics and pharmacogenetics.
WJ Greenlee, MC Desai
Current Opinion in Drug Discovery & Development 2002, 5:475-476 (31July2002)
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Review
Osteoporosis: Challenges and new opportunities for therapy.
DP Rotella
Current Opinion in Drug Discovery & Development 2002, 5:477-486 (31July2002)
[PDF] [PubMed] [Related articles]
Review
Recent advances in the discovery of small molecule histone deacetylase inhibitors.
SW Remiszewski
Current Opinion in Drug Discovery & Development 2002, 5:487-499 (31July2002)
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Review
Recent advances in the development of small molecule inhibitors of PTP1B for the treatment of insulin resistance and type 2 diabetes.
JF Tobin, S Tam
Current Opinion in Drug Discovery & Development 2002, 5:500-512 (31July2002)
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Review
Recent advances in the development of g-secretase inhibitors.
H Josien
Current Opinion in Drug Discovery & Development 2002, 5:513-525 (31July2002)
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Review
Drug discovery and development using chemical genomics.
A Sehgal
Current Opinion in Drug Discovery & Development 2002, 5:526-531 (31July2002)
[PDF] [PubMed] [Related articles]
Review
Chemical genomics: Bridging the gap between the proteome and therapeutics.
D Falb, S Jindal
Current Opinion in Drug Discovery & Development 2002, 5:532-539 (31July2002)
[PDF] [PubMed] [Related articles]
Review
Guiding molecules towards drug-likeness.
WJ Egan, WP Walters, MA Murcko
Current Opinion in Drug Discovery & Development 2002, 5:540-549 (31July2002)
[PDF] [PubMed] [Related articles]
Review
Designing selective COX-2 inhibitors: Molecular modeling approaches.
G Trummlitz, Ryn J van
Current Opinion in Drug Discovery & Development 2002, 5:550-561 (31July2002)
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Review
Microsomal triglyceride transfer protein (MTP) inhibitors: Discovery of clinically active inhibitors using high-throughput screening and parallel synthesis paradigms.
G Chang, RB Ruggeri, Jr HJ Harwood
Current Opinion in Drug Discovery & Development 2002, 5:562-570 (31July2002)
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Review
New developments in chemical library synthesis. Norbornenyl tags for use in phase-switching,
sequestration, capture-release and soluble support applications.
DL Flynn, PR Hanson, SC Berk, GM Makara
Current Opinion in Drug Discovery & Development 2002, 5:571-579 (31July2002)
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Review
Recent advances in chemical library synthesis methodology.
DL Flynn, SC Berk, GM Makara
Current Opinion in Drug Discovery & Development 2002, 5:580-593 (31July2002)
[PDF] [PubMed] [Related articles]
Review
Solid-phase compound library synthesis in drug design and development.
PJ Edwards, AI Morrell
Current Opinion in Drug Discovery & Development 2002, 5:594-605 (31July2002)
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Review
Membrane array technology for drug discovery.
JT Groves
Current Opinion in Drug Discovery & Development 2002, 5:606-612 (31July2002)
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Review
Using X-ray crystallography in drug discovery.
RS Rowland
Current Opinion in Drug Discovery & Development 2002, 5:613-619 (31July2002)
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Review
Recent trends in microwave-assisted synthesis.
NS Wilson, GP Roth
Current Opinion in Drug Discovery & Development 2002, 5:620-629 (31July2002)
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Review
NMR-based approaches for lead discovery.
DF Wyss, MA McCoy, MM Senior
Current Opinion in Drug Discovery & Development 2002, 5:630-647 (31July2002)
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Paper alert
Paper alert
J Hirst, P Norman, DP Rotella
Current Opinion in Drug Discovery & Development 2002, 5:649-667 (18September2002)
[PDF]
Patent alert
Patent alert
B Swords
Current Opinion in Drug Discovery & Development 2002, 5:668-678 (18September2002)
[PDF]
Web alert
Web alert
D Cavalla
Current Opinion in Drug Discovery & Development 2002, 5:679-680 (18September2002)
[PDF]
Editorial overview
The chemistry of biological processes.
JA Lowe, CH Hill, FD King
Current Opinion in Drug Discovery & Development 2002, 5:681-682 (18September2002)
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Review
Integrated approaches to therapeutic target gene discovery.
KM DeFife, F Wong-Staal
Current Opinion in Drug Discovery & Development 2002, 5:683-689 (18September2002)
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Review
Aptamers and aptazymes: Accelerating small molecule drug discovery.
P Burgstaller, A Jenne, M Blind
Current Opinion in Drug Discovery & Development 2002, 5:690-700 (18September2002)
[PDF] [PubMed] [Related articles] [Cited on BioMed Central]
Review
Targeting protein kinases in cancer therapy.
D Fabbro, C Garcia-Echeverria
Current Opinion in Drug Discovery & Development 2002, 5:701-712 (18September2002)
[PDF] [PubMed] [Related articles]
Review
Kinases as targets: Prospects for chronic therapy.
S Orchard
Current Opinion in Drug Discovery & Development 2002, 5:713-717 (18September2002)
[PDF] [PubMed] [Related articles]
Review
Protein kinase inhibitors from the urea class.
J Dumas
Current Opinion in Drug Discovery & Development 2002, 5:718-727 (18September2002)
[PDF] [PubMed] [Related articles]
Review
Bioactive lipids and their receptors.
I Angel, A Bar, R Haring
Current Opinion in Drug Discovery & Development 2002, 5:728-740 (18September2002)
[PDF] [PubMed] [Related articles]
Review
The inner workings of AMPA receptors.
DR Madden
Current Opinion in Drug Discovery & Development 2002, 5:741-748 (18September2002)
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Review
Allosteric modulation of G protein-coupled receptors.
W Soudjin, Wijngaarden I van, AP IJzerman
Current Opinion in Drug Discovery & Development 2002, 5:749-755 (18September2002)
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Review
Formation of oligomers by G protein-coupled receptors.
L Gazi, JF Lopez-Gimenez, PG Strange
Current Opinion in Drug Discovery & Development 2002, 5:756-763 (18September2002)
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Review
Targeting neurotensin receptors with agonists and antagonists for therapeutic purposes.
P Kitabgi
Current Opinion in Drug Discovery & Development 2002, 5:764-776 (18September2002)
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Review
Internal initiation of translation by viral and cellular IRESs - A new avenue for specific inhibition of protein synthesis?
J Gallego
Current Opinion in Drug Discovery & Development 2002, 5:777-784 (18September2002)
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Review
Novel approaches to antimicrobial therapy: Peptide deformylase.
AS Waller, JM Clements
Current Opinion in Drug Discovery & Development 2002, 5:785-792 (18September2002)
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